ncRNA name | hsa-miR-18a |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB samples, normal retina tissues; human RB cell line Y79 |
Methods | qRT-PCR, transfection, MTT assay, transwell assay, Western blot, Caspase-3 assay |
Expression pattern | up-regulated |
Functional description | This study has showed varied expression of the miR17-92 cluster in primary RB tumors. EpCAM influences miR 17-92 cluster expression in retinoblastoma. In addition, we showed that the miR 17-92 cluster plays a role in RB cell proliferation and invasion. |
PubMed ID | 22969266 |
Year | 2012 |
Title | Oncogenic microRNA 17-92 cluster is regulated by epithelial cell adhesion molecule and could be a potential therapeutic target in retinoblastoma. |
Drug-related ncRNA | NO |
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